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Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels,〔The rectum has numerous amounts of blood vessels available to absorb drugs.〕 and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems.〔The organs and systems include, depending on if the drug is able to pass the blood–brain barrier (BBB) or not, the central nervous system (CNS), peripheral nervous system (PNS), cardiovascular system (CVS), et cetera.〕 A drug that is administered rectally will in general (depending on the drug) have a faster onset, higher bioavailability, shorter peak, and shorter duration than the oral route.〔De Boer AG, Moolenaar F, de Leede LG, Breimer DD. (1982) "Rectal drug administration: clinical pharmacokinetic considerations." ''Clin Pharmacokinetics''. 7(4):285–311〕〔Moolenaar F, Koning B, Huizinga T. (1979) "Biopharmaceutics of rectal administration of drugs in man. Absorption rate and bioavailability of phenobarbital and its sodium salt from rectal dosage forms." International Journal of Pharmacaceutics, 4:99–109〕 Another advantage of administering a drug rectally, is that it tends to produce less nausea compared to the oral route and prevents any amount of the drug from being lost due to emesis (vomiting). In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic (middle and inferior rectal vein) and one third portal (superior rectal vein). This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations.〔Other ROAs that bypass first-pass metabolism include inhalation (smoking, vaporizing, etc.), intravenous injection (IV), insufflation ("snorting"), et cetera, but the oral route does not bypass first-pass metabolism.〕 Finally, rectal administration can allow patients to remain in the home setting when the oral route is compromised. Unlike intravenous lines, which usually need to be placed in an inpatient environment and require special formulation of sterile medications,〔Plumer AL. 2007. ''Plumer's Principles and Practices of Intravenous Therapy''. Lippincott Williams & Wilkins. 753 pp.〕 a specialized rectal catheter can be placed by a clinician, such as a hospice nurse or home health nurse, in the home. Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients who cannot swallow, including those near the end of life (an estimated 1.65 million people are in hospice care in the US each year).〔("National Hospice and Palliative Care Organization's Facts and Figures: Hospice Care in America, 2013 Edition" (PDF) )〕 Because using the rectal route enables a rapid, safe, and lower cost alternative to administration of medications,〔(A Quality Improvement Study: Use of a Rectal Medication Administration Device Intervention to manage end-stage symptoms in hospice patients when the oral route fails. Poster Presentations. 6th Annual Hospice Palliative Nurses Association Clinical Practice Forum, Pittsburgh, PA, September 15-15, 2012 )〕 it may also facilitate the care of patients in long-term care or palliative care, or as an alternative to intravenous or subcutaneous medication delivery in other instances. ==Methods== Rectal administration of medication may be performed with any of the following: *A suppository, a drug delivery system inserted into the rectum. *An enema, the act of introducing a liquid-drug solution (drug(s) dissolved in water, the amount usually being less than 10 millilitres) into the rectum and sometimes the colon (usually when more liquid is used). *A specialized catheter designed for rectal administration of medications and liquids, that can be placed safely and remain comfortably in the rectum for repeated use. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Rectal administration」の詳細全文を読む スポンサード リンク
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